The UK broadcaster bought the rights to the entire nine-part series, but only has space in its schedule to show eight programmes before Euro 2008 begins.
Viewers will skip straight to episode three of the modern-day fairytale, about a man who brings people back from the dead - including his first love.
Episode one brought 5.7 million viewers to ITV1 on Saturday night.
"Episode two was the only show we could drop without spoiling the storyline," an ITV spokesman said.
The missing instalment sees lead character Ned coming to terms with his power, interspersed with flashbacks to his childhood - including a school lesson where he was expected to dissect a frog.
As with the first episode, it was directed by Men In Black and Addams Family film-maker Barry Sonnenfeld.
However, ITV said the programme would "be shown at some point because the series will be repeated".
The broadcaster said its decision was due to the US writers' strike, which meant only nine episodes of Pushing Daisies were made.
The series has made former Brookside star Anna Friel a household name in the US.
It won her a Golden Globe nomination for best actress, although she was beaten to the prize by Tina Fey, who writes and stars in comedy series 30 Rock.
A second series is due to start filming later this year.

"Episode two was the only show we could drop without spoiling the storyline," an ITV spokesman said.

I love Tremors. Excellent film, that.

There are 2 more mother humpers.

Really?

Do they regularly swear in the Simpsons and it is later edited out?

I remember an episode of Hey Arnold where Helga went to Wankyland.

Wanker is a semi-common surname in America. In Married With Children Perry's maiden name was Wanker. It's not a rude word.

cant forget the classic,

yippee kiyay, mister falcon.