Something else ocurred to me that I wondered what other people about:
ZOMG Spoiler! Click here to view!
At the point when they're in the basement after Mike goes off to look for Josh the group go through the flamethrower guy's stuff and start reading his journal. They get to the bit that mentions how if you kill a wendigo the spirit is released to look for another host and Sam's all like, "Shit, we need to tell Mike." I assumed at the time she meant that as in, we need to tell him not to actually kill and wendigos or he'll just get possessed by the released spirit. And for the rest of the game, whenever you kill one you do see the spirit released and floating around but nothing actually ever comes of that does it? It just seemed a bit odd to make a big deal of the whole concept and always show the spirits flying loose but never make anything of it.